Sneddon's syndrome, presented at first with intracranial hemorrhage: A case report

Sneddon's syndrome is characterized by chronic, progressive arteriopathy that causes ischemic stroke and skin lesions. It seems that thrombotic or embolic process in vessels may have role in its pathology. Neurological symptoms are always due to ischemic event of cerebrovascular system and skin manifestations include deep blue skin lesions with irregular margins called livedo reticularis and livedo racemosa. However, in spite of ischemic event, hemorrhagic cerebral accidents are unusual in this syndrome. Our case was apparently a normal woman with negative past medical history who, despite of usual ischemic cerebral manifestations, developed intracranial hemorrhage at first and after a few days to new skin lesions (livedo reticularis). In the follow-up she was diagnosed with sneddon's syndrome.